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肾移植后红细胞增多症的危险因素。

Risk factors of erythrocytosis post renal transplantation.

作者信息

Razeghi Effat, Kaboli Alireza, Pezeshki Mahboob Lessan, Meysamie Ali Pasha, Khatami Mohammad Reza, Khashayar Patricia

机构信息

Sina Hospital, Tehran, Iran.

出版信息

Saudi J Kidney Dis Transpl. 2008 Jul;19(4):559-63.

Abstract

Post-transplant erythrocytosis (PTE) is characterized by persistently elevated hematocrit level >or= 51%. This complication is reported to develop in 10-20% of renal allografts recipients, mostly 2 years after kidney transplantation. PTE is self-limited in 25% of the patients; however it may persist in patients with an increased susceptibility for thrombosis and potential fatal outcome. To evaluate the prevalence and risk factors of PTE in our center, we reviewed the records of 235 patients who received renal allografts from 1999 to 2004. Polycythemia was found in 45 (19%) patients. There was no significant correlation of polycythemia and age, history of hypertension, diabetes, pre-transplant hematocrit level, pre-transplant history of transfusion, graft's function, and source of kidney. A significantly higher proportion of PTE patients were males, patients with history of polycystic kidney disease, and patients with glomerulonephritis. We conclude that PTE is an important complication of kidney transplantation. There are several risk factors that should be addressed to prevent this complication.

摘要

移植后红细胞增多症(PTE)的特征是血细胞比容水平持续升高≥51%。据报道,这种并发症在10%至20%的肾移植受者中出现,大多在肾移植后2年发生。25%的患者中PTE为自限性;然而,在血栓形成易感性增加且可能出现致命后果的患者中,PTE可能会持续存在。为了评估我们中心PTE的患病率和危险因素,我们回顾了1999年至2004年接受肾移植的235例患者的记录。45例(19%)患者出现红细胞增多症。红细胞增多症与年龄、高血压病史、糖尿病、移植前血细胞比容水平、移植前输血史、移植物功能以及肾脏来源均无显著相关性。PTE患者中男性、多囊肾病患者和肾小球肾炎患者的比例显著更高。我们得出结论,PTE是肾移植的一种重要并发症。有几个危险因素需要加以关注以预防这种并发症。

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