Charfeddine K, Zaghdane S, Yaich S, Hakim A, Hachicha J
Department of Renal Transplantation, University Hospital, SFAX - Tunisia.
Saudi J Kidney Dis Transpl. 2008 May;19(3):371-7.
A retrospective study was conducted on 143 consecutive renal transplant recipients who had a functioning graft for three months or longer, to evaluate the prevalence of post-transplant erythrocytosis (PTE) and its potential risk factors. True PTE was defined as hematocrit (Ht) above 52% and hemoglobin (Hb) above 18 g/dl in males, and Ht above 50% and Hb above 17 g /dl in females. A total of 31 patients (21.6%) developed PTE; none had any evidence of polycythemia vera (PV), or secondary polycythemia due to reduced arterial oxygen, kidney or hepatic tumors, or relative erythrocytosis due to a decrease in plasma volume by overuse of diuretics. Thirty-one non-polycythemic patients (Hb 12.9 +-1.6 g/dl) matched for sex, age and renal function were used as case controls. PTE was more common in males (p= 0.043). The majority of our patients developed PTE within the first year post-transplantation and all had excellent renal function at the time of diagnosis. Also, PTE was found to be related to duration on dialysis prior to transplantation (p= 0.0013) and acute rejection (p= 0.0031).
对143例连续的肾移植受者进行了一项回顾性研究，这些受者的移植肾已正常工作3个月或更长时间，以评估移植后红细胞增多症（PTE）的患病率及其潜在危险因素。真正的PTE定义为男性血细胞比容（Ht）高于52%且血红蛋白（Hb）高于18 g/dl，女性Ht高于50%且Hb高于17 g/dl。共有31例患者（21.6%）发生了PTE；均无真性红细胞增多症（PV）或因动脉血氧降低、肾脏或肝脏肿瘤导致的继发性红细胞增多症，也无因过度使用利尿剂导致血浆量减少引起的相对性红细胞增多症的证据。选取31例非红细胞增多症患者（Hb 12.9±1.6 g/dl）作为病例对照，这些患者在性别、年龄和肾功能方面相匹配。PTE在男性中更为常见（p = 0.043）。我们的大多数患者在移植后的第一年内发生了PTE，并且在诊断时肾功能均良好。此外，发现PTE与移植前透析时间（p = 0.0013）和急性排斥反应（p = 0.0031）有关。
