Adhihetty Peter J, O'Leary Michael F N, Hood David A
Department of Neurology and Neuroscience, Cornell University, New York, New York, USA.
Exerc Sport Sci Rev. 2008 Jul;36(3):116-21. doi: 10.1097/JES.0b013e31817be7b7.
Apoptosis is an essential process that plays a critical role in both tissue development and maintenance. Apoptosis has been shown to be involved in skeletal muscle atrophy resulting from chronic muscular disuse, sarcopenia, and mitochondrial myopathies. Exercise may attenuate some of the proapoptotic adaptations that occur during these conditions. This review will focus on the factors influencing mitochondrially mediated apoptosis in skeletal muscle.
细胞凋亡是一个重要过程，在组织发育和维持中都起着关键作用。细胞凋亡已被证明与慢性肌肉废用、肌肉减少症和线粒体肌病导致的骨骼肌萎缩有关。运动可能会减弱这些情况下发生的一些促凋亡适应性变化。本综述将聚焦于影响骨骼肌线粒体介导的细胞凋亡的因素。
