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Drug discovery: a lifeline for suffocating tissues.

作者信息

Mazzone Massimiliano, Carmeliet Peter

出版信息

Nature. 2008 Jun 26;453(7199):1194-5. doi: 10.1038/4531194a.

DOI:10.1038/4531194a
PMID:18580938
Abstract
摘要

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Drug discovery: a lifeline for suffocating tissues.药物研发：窒息组织的生命线。
Nature. 2008 Jun 26;453(7199):1194-5. doi: 10.1038/4531194a.
2
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Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium.通过纳米技术介导匹伐他汀细胞选择性递送至血管内皮实现治疗性血管新生
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Gene therapy with the angiogenic cytokine secretoneurin induces therapeutic angiogenesis by a nitric oxide-dependent mechanism.使用血管生成细胞因子分泌神经元进行基因治疗可通过一氧化氮依赖性机制诱导治疗性血管生成。
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Vascular caveolin deficiency supports the angiogenic effects of nitrite, a major end product of nitric oxide metabolism in tumors.血管小窝蛋白缺乏增强了亚硝酸盐的血管生成作用，亚硝酸盐是肿瘤中一氧化氮代谢的主要终产物。
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Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase.普伐他汀通过AMP激活的蛋白激酶加速缺血诱导的血管生成。
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[Changes and reactions produced by lytic substances (acetic acid, nitric acid) in normal tissues. I. Effects on vasculo-nervous fasciae].[正常组织中溶解性物质（乙酸、硝酸）产生的变化及反应。I. 对血管神经筋膜的影响]
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Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.过氧化物酶体增殖物激活受体δ激动剂通过磷脂酰肌醇3激酶/蛋白激酶B途径的基因组和非基因组激活来调节内皮祖细胞，从而增强血管生成。
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The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.
驱虫剂 N,N-二乙基间甲苯酰胺（DEET）通过对内皮细胞中 M3 毒蕈碱受体的变构调节诱导血管生成。
Sci Rep. 2016 Jun 27;6:28546. doi: 10.1038/srep28546.
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Review focus on inorganic nitrite and nitrate in cardiovascular health and disease.综述聚焦于无机亚硝酸盐和硝酸盐在心血管健康与疾病中的作用。
Cardiovasc Res. 2011 Feb 15;89(3):489-91. doi: 10.1093/cvr/cvq409. Epub 2010 Dec 23.
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Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases.无机亚硝酸盐与慢性组织缺血：外周血管疾病的一种新型治疗方式。
Cardiovasc Res. 2011 Feb 15;89(3):533-41. doi: 10.1093/cvr/cvq297. Epub 2010 Sep 16.
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Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro.CD47信号的神经血管效应：体外促进脑内皮细胞的细胞死亡、炎症并抑制血管生成
J Neurosci Res. 2009 Aug 15;87(11):2571-7. doi: 10.1002/jnr.22076.
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Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.使用综合代谢组学/蛋白质组学方法对亚硝酸盐诱导的心脏保护作用的机制性见解。
Circ Res. 2009 Mar 27;104(6):796-804. doi: 10.1161/CIRCRESAHA.108.187005. Epub 2009 Feb 19.
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Nitrite as regulator of hypoxic signaling in mammalian physiology.亚硝酸盐作为哺乳动物生理学中缺氧信号的调节因子。
Med Res Rev. 2009 Sep;29(5):683-741. doi: 10.1002/med.20151.
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Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy.在缺血性疾病期间维持血管功能：无机亚硝酸盐疗法的新可能性。
Expert Rev Cardiovasc Ther. 2008 Oct;6(9):1175-9. doi: 10.1586/14779072.6.9.1175.
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Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems.缺氧状态下亚硝酸盐的组织处理：一氧化氮生成与清除系统的复杂相互作用
J Biol Chem. 2008 Dec 5;283(49):33927-34. doi: 10.1074/jbc.M806654200. Epub 2008 Oct 3.