Galectin-3和HBME-1在颗粒细胞瘤中的免疫组化表达：一项新发现。

Immunohistochemical expression of Galectin-3 and HBME-1 in granular cell tumors: a new finding.

作者信息

Bellezza Guido, Colella Renato, Sidoni Angelo, Del Sordo Rachele, Ferri Ivana, Cioccoloni Claudia, Cavaliere Antonio

机构信息

Institute of Pathologic Anatomy and Histology, Division of Cancer Research, University of Perugia, Perugia, Italy.

出版信息

Histol Histopathol. 2008 Sep;23(9):1127-30. doi: 10.14670/HH-23.1127.

DOI:10.14670/HH-23.1127

PMID:18581283

Abstract

Granular cell tumor (GCT) is a relatively rare neoplasm, usually located in the upper aerodigestive tract, skin and soft tissue. Because of its uncertain histogenesis, GCT has been the object of many immunohistochemical and ultrastructural studies that have suggested a Schwann cell origin. Our recent observation of a case of GCT immunoreactive for Galectin-3 and HBME-1 led us to further investigate the immunohistochemical profile of these neoplasms. We evaluated the immunohistochemical expression of the traditional markers for GCT (S-100, CD68) along with new markers (Galectin-3, HBME-1, Calretinina and Inhibin-alpha) in 22 granular cell tumors. Our results showed, in all cases, a constant diffuse positivity for S-100 protein, CD68 and Galectin-3. HBME-1 was positive in 95% of cases. The present study gives a new immunophenotypic profile for GCT, which could help pathologists in distinguishing morphologically ambiguous granular lesions in unusual sites.

摘要

颗粒细胞瘤（GCT）是一种相对罕见的肿瘤，通常位于上消化道、皮肤和软组织。由于其组织发生尚不明确，颗粒细胞瘤一直是许多免疫组织化学和超微结构研究的对象，这些研究提示其起源于施万细胞。我们最近观察到1例对半乳糖凝集素-3和HBME-1呈免疫反应性的颗粒细胞瘤病例，这促使我们进一步研究这些肿瘤的免疫组织化学特征。我们评估了22例颗粒细胞瘤中颗粒细胞瘤传统标志物（S-100、CD68）以及新标志物（半乳糖凝集素-3、HBME-1、钙视网膜蛋白和抑制素-α）的免疫组织化学表达。我们的结果显示，在所有病例中，S-100蛋白、CD68和半乳糖凝集素-3均呈持续弥漫性阳性。HBME-1在95%的病例中呈阳性。本研究给出了颗粒细胞瘤新的免疫表型特征，这有助于病理学家鉴别不寻常部位形态学上模棱两可的颗粒性病变。