El-Khalawany Mohamed, Mosbeh Al-Sadat, Abd-Al Salam Fatma, Abou-Bakr Amany
Department of Dermatology, Al-Hussein University Hospital, Al-Azhar University, Box 32515, Al-Darasah, Cairo, Egypt.
J Skin Cancer. 2011;2011:497648. doi: 10.1155/2011/497648. Epub 2011 Nov 1.
Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions.
颗粒细胞瘤(GCT)很少表现为皮肤溃疡。我们检查了14例这种溃疡性形式的临床病理和免疫组化特征,这可能会提高对这种变体的认识。该研究包括11名男性和3名女性,平均年龄为31.5±7.42岁。所有病例均表现为单个大溃疡,底部硬结,边界隆起,边缘肤色,底部坏死。12个病变位于四肢,2个病变位于生殖器区域。组织学上,病变显示真皮浸润,由大的多边形细胞组成,细胞质呈颗粒状,所有病例均有真皮肌肉的特征性浸润。免疫染色显示S100(14/14)、NSE(14/14)、CD68(5/14)和波形蛋白(7/14)呈阳性反应,而HMB45、细胞角蛋白(CK)、上皮膜抗原(EMA)和平滑肌肌动蛋白(Desmin)均为阴性。我们希望本文能提高对溃疡性GCT的认识,并在溃疡性病变的鉴别诊断中考虑到它。