Imbelloni L E, Gouveia M A, Cordeiro J A
Institute for Regional Anesthesia-Hospital de Base da FAMERP, São José do Rio Preto, SP, Brazil.
Acta Anaesthesiol Scand. 2008 Jul;52(6):856-61. doi: 10.1111/j.1399-6576.2007.01511.x.
Spinal anesthesia with the local anesthetic lidocaine has come under scrutiny because it is associated with transient neurologic symptoms (TNS). Although TNS is not associated with either lidocaine concentration or dose, its incidence has never been examined with very small doses of hyperbaric spinal lidocaine in patients in the lithotomy position. We designed this study prospectively to compare the efficacy of low-dose 15 mg/ml with low-dose 20 mg/ml hyperbaric lidocaine in patients undergoing elective outpatient surgery in the lithotomy position.
A total of 100 patients were randomized to receive either 30 mg of 15 mg/ml or the same dose of 20 mg/ml hyperbaric lidocaine. Lidocaine density at 37 degrees C is 1.0241 g/ml for the 15 mg/ml and 1.0260 g/ml for the 20 mg/ml solution. Patients were examined for motor block, sensory block, and block duration. Patients were contacted at 24, 48 and 72 h and questioned about their perceptions of pain after the spinal anesthesia with specific questions designed to diagnose TNS.
The spread of analgesia was the same with both solutions of lidocaine. Motor block was incomplete in all patients in both groups. TNS were not observed when low doses of both solutions of lidocaine with dextrose were used in these ambulatory patients in the lithotomy position.
Hyperbaric lidocaine results in rapid recovery from sensory block and motor blockade. It may have advantages for patients in a day-case setting. No patients complained of TNS after discharge.
使用局部麻醉药利多卡因进行脊髓麻醉受到了审查,因为它与短暂性神经症状(TNS)有关。尽管TNS与利多卡因的浓度或剂量均无关,但其发生率从未在截石位患者中使用极小剂量的高压脊髓利多卡因进行过研究。我们前瞻性地设计了这项研究,以比较15mg/ml低剂量与20mg/ml低剂量高压利多卡因在接受截石位择期门诊手术患者中的疗效。
总共100例患者被随机分配接受30mg的15mg/ml或相同剂量的20mg/ml高压利多卡因。37摄氏度时,15mg/ml利多卡因溶液的密度为1.0241g/ml,20mg/ml溶液的密度为1.0260g/ml。对患者进行运动阻滞、感觉阻滞和阻滞持续时间的检查。在24、48和72小时与患者联系,询问他们在脊髓麻醉后对疼痛的感受,并通过专门设计的问题来诊断TNS。
两种利多卡因溶液的镇痛范围相同。两组所有患者的运动阻滞均不完全。在这些截石位的门诊患者中,当使用两种含葡萄糖的低剂量利多卡因溶液时,未观察到TNS。
高压利多卡因可使感觉阻滞和运动阻滞迅速恢复。对于日间手术患者可能具有优势。出院后没有患者抱怨TNS。