Picconi Barbara, Ghiglieri Veronica, Bagetta Vincenza, Barone Ilaria, Sgobio Carmelo, Calabresi Paolo
Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c/o CERC, Via del Fosso di Fiorano 64, Rome, Italy.
Parkinsonism Relat Disord. 2008;14 Suppl 2:S145-9. doi: 10.1016/j.parkreldis.2008.04.019. Epub 2008 Jun 25.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic terminals from substantia nigra pars compacts, which leads to the motor symptoms observed in this disorder. L-Dopa administration represents the most effective therapeutic treatment of PD, but the development of disabling dyskinetic movements is a dramatic consequence of the treatment. The organization and functional interactions of glutamate receptors within the striatum appear to be crucial both in the pathogenesis of PD and in the development of dyskinesia. At the molecular level, it has become increasingly evident that the glutamatergic NMDA receptor complex is a dynamic structure that is involved in the regulation of corticostriatal long-term synaptic changes, which is altered in experimental PD and in dyskinesia.
帕金森病（PD）是一种神经退行性疾病，其特征是黑质致密部多巴胺能终末进行性退化，这导致了该疾病中出现的运动症状。左旋多巴给药是PD最有效的治疗方法，但致残性运动障碍的出现是该治疗的一个严重后果。纹状体内谷氨酸受体的组织和功能相互作用在PD的发病机制和运动障碍的发展中似乎都至关重要。在分子水平上，越来越明显的是，谷氨酸能N-甲基-D-天冬氨酸（NMDA）受体复合物是一种动态结构，参与皮质纹状体长期突触变化的调节，而在实验性PD和运动障碍中这种调节会发生改变。
