Katz Michael G, Finkelshtein Vitaly, Raichman Dominique Ben-Ami, Dekel Hagi, Lampl Yair, Sasson Lior
Department of Cardiothoracic Surgery, E. Wolfson Medical Center, Holon, Israel.
Heart Surg Forum. 2008;11(3):E169-71. doi: 10.1532/HSF98.20081015.
Brain ischemia resulting from left atrial myxoma embolization has been well documented. In contrast, the link between the development of intracerebral hemorrhage and myxoma in these patients has little coverage in the literature. The main theory describing this relationship stems from the fact that cardiac myxoma cells metastasize to the brain's vessels, causing destruction of the arterial wall with subsequent formation of fusiform aneurysm and further intracranial bleeding. It is assumed that when a diagnosis of left atrial myxoma with neurologic manifestations is made, surgical resection should be performed without delay to prevent repeated tumor embolization; however, systemic anticoagulation treatment during cardiac surgery with cardiopulmonary bypass is not recommended immediately after intracerebral hemorrhage occurs because of the possibility of extending the infarct's size. We describe a patient with acute hemorrhagic brain infarction and an echocardiographically demonstrated left atrial myxoma that was surgically resected successfully in the acute phase after the onset of the neurologic symptoms.
左心房黏液瘤栓塞导致脑缺血已有充分文献记载。相比之下,这些患者脑内出血与黏液瘤之间的联系在文献中报道较少。描述这种关系的主要理论源于心脏黏液瘤细胞转移至脑血管,导致动脉壁破坏,随后形成梭形动脉瘤并进一步引发颅内出血。一般认为,当诊断出患有伴有神经症状的左心房黏液瘤时,应立即进行手术切除以防止肿瘤反复栓塞;然而,脑出血发生后,由于可能扩大梗死面积,不建议在体外循环心脏手术期间立即进行全身抗凝治疗。我们描述了一名患有急性出血性脑梗死且经超声心动图证实为左心房黏液瘤的患者,该患者在神经症状出现后的急性期成功接受了手术切除。