Lashley P M, Callender D P, Graham A C, Gopwani H, Garriques S
Department of Paediatrics, Queen Elizabeth Hospital, Barbados.
West Indian Med J. 1991 Mar;40(1):37-40.
A case is described of a 3-year-old boy with acute lymphoblastic leukaemia (ALL) who presented initially with aspergillosis of the nasopharynx. Fungal infection with Aspergillus species is not uncommon in immunosuppressed children, but this case is noteworth in that the disease presented at the onset of therapy rather than during the phase of treatment, with maximum immunosuppression following chemotherapy. This type of infection is usually associated with the treatment of acute non-lymphoblastic leukaemias (AML) rather than ALL, and prolonged periods of neutropenia which results from aggressive treatment. This patient responded rapidly to treatment with amphotericin B, coincident with resolution of his neutropenia as the underlying disease was treated, eventually eradicating the fungus.
本文描述了一名3岁急性淋巴细胞白血病（ALL）男孩的病例，该男孩最初表现为鼻咽曲霉菌病。曲霉菌属真菌感染在免疫抑制儿童中并不罕见，但该病例值得注意的是，疾病在治疗开始时而非治疗阶段出现，化疗后免疫抑制达到最大程度。这种感染类型通常与急性非淋巴细胞白血病（AML）的治疗相关，而非ALL，且与积极治疗导致的长期中性粒细胞减少有关。该患者对两性霉素B治疗反应迅速，随着基础疾病的治疗中性粒细胞减少症得到缓解，最终根除了真菌。
