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[伊曲康唑治疗急性白血病患者侵袭性支气管肺曲霉病]

[Invasive bronchopulmonary aspergillosis treated with itraconazole in a patient with acute leukemia].

作者信息

Sarcía-Ruiz J C, Alvarez C, Floristán F, Hernández I, Hernández J, Alvarez Blanco A, Ponton J

机构信息

Sección Clínica-Citología, Hospital de Cruces, Baracaldo, Vizcaya.

出版信息

Sangre (Barc). 1993 Oct;38(5):399-402.

PMID:8140504
Abstract

A case of invasive broncopulmonar aspergillosis caused by Aspergillus terreus successfully treated with itraconazole is reported in a patient undergoing autologous bone marrow transplantation for acute lymphoblastic leukaemia. Although the patient was on prophylaxis with fluconazole and she did not respond to amphotericin B, there was an excellent response to itraconazole which allowed the transplant without any Aspergillus infection during both the transplant and the post-transplant periods. Due to its oral administration, good tolerance and low toxicity, itraconazole is a promising drug for the treatment of invasive broncopulmonar aspergillosis.

摘要

本文报道了1例侵袭性支气管肺曲霉病患者,该患者因急性淋巴细胞白血病接受自体骨髓移植,由土曲霉引起,采用伊曲康唑成功治疗。尽管该患者接受了氟康唑预防治疗,且对两性霉素B无反应,但对伊曲康唑有良好反应,使得移植过程及移植后均未发生任何曲霉感染。由于伊曲康唑可口服,耐受性好且毒性低,它是治疗侵袭性支气管肺曲霉病的一种有前景的药物。

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