Claria J, Jimenez W, La Villa G, Asbert M, Castro A, Llibre J L, Arroyo V, Rivera F
Hormonal Laboratory Hospital Clínic i Provincial, Barcelona, Spain.
Acta Physiol Scand. 1991 Mar;141(3):305-8. doi: 10.1111/j.1748-1716.1991.tb09085.x.
The effects of endothelin (100 and 600 pmol/kg) on renal plasma flow (RPF), glomerular filtration rate (GFR), sodium excretion (UNa V) and segmental sodium handling were investigated in conscious rats. Low-dose endothelin decreased renal plasma flow by 26% without affecting glomerular filtration rate and sodium excretion. High-dose endothelin reduced renal plasma flow, glomerular filtration rate, sodium excretion and lithium clearance by 57, 45, 38 and 52%, respectively. The fall in sodium excretion was not due to a direct effect of endothelin on tubular sodium transport since sodium excretion corrected by glomerular filtration rate and fractional proximal and distal sodium reabsorption did not change throughout the study. These results indicate that the impairment in renal perfusion is responsible for the antinatriuretic effect of endothelin in conscious rats.
在清醒大鼠中研究了内皮素（100和600 pmol/kg）对肾血浆流量（RPF）、肾小球滤过率（GFR）、钠排泄（UNa V）和节段性钠处理的影响。低剂量内皮素使肾血浆流量降低26%，而不影响肾小球滤过率和钠排泄。高剂量内皮素使肾血浆流量、肾小球滤过率、钠排泄和锂清除率分别降低57%、45%、38%和52%。钠排泄的下降并非由于内皮素对肾小管钠转运的直接作用，因为在整个研究过程中，经肾小球滤过率校正的钠排泄以及近端和远端钠重吸收分数均未改变。这些结果表明，肾灌注受损是内皮素在清醒大鼠中产生利钠作用的原因。
