利用末端堆积能力检测G-四链体中的结构转换。

Detection of structure-switching in G-quadruplexes using end-stacking ability.

作者信息

Seo Young Jun, Lee Il Joon, Kim Byeang Hyean

机构信息

Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3910-3. doi: 10.1016/j.bmcl.2008.06.033. Epub 2008 Jun 14.

DOI:10.1016/j.bmcl.2008.06.033

PMID:18585032

Abstract

G-quadruplex-forming ODNs containing nonpolar aromatic fluorophore moiety, A(PY) at the dangling ends undergo pi-stacking on surface of G-quadruplex, and the fluorescence change can be used to distinguish the structure-switching between the mixed parallel/antiparallel structure and antiparallel structure.

摘要

在悬垂末端含有非极性芳香族荧光团A(PY)的形成G-四链体的寡核苷酸在G-四链体表面发生π-堆积，并且荧光变化可用于区分混合平行/反平行结构与反平行结构之间的结构转换。