Mierzejewski Pawel, Olczak Mieszko, Rogowski Artur, Kostowski Wojciech, Samochowiec Jerzy, Filip Malgorzata, Przegalinski Edmund, Bienkowski Przemyslaw
Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957, Warsaw, Poland.
Neurosci Lett. 2008 Aug 29;441(3):307-10. doi: 10.1016/j.neulet.2008.06.047. Epub 2008 Jun 21.
Little is known about the role of new protein synthesis in extinction of operant responding for natural and chemical reinforcers. In the present study, the authors investigated whether the effects of a protein synthesis inhibitor, cycloheximide (CHX) on extinction of operant responding for sweet reward depended on the duration of re-exposure sessions. In addition, the authors investigated whether the effects of CHX on extinction could generalize to relapse of saccharin seeking induced by discrete cues. CHX injected after short re-exposure sessions (5min) accelerated extinction of non-reinforced responding. In contrast, the drug injected after long re-exposure sessions (30min) partially inhibited extinction. Reinstatement of saccharin seeking induced by the saccharin-paired discrete cues was not altered by the previous treatment with CHX. Concluding, the results of the present study indicate that: (i) the protein synthesis inhibitor, CHX can alter extinction of operant responding for sweet reward in rats; (ii) the effects of CHX on extinction critically depend on the duration of re-exposure/extinction sessions and do not generalize to relapse of saccharin seeking induced by discrete cues.
关于新蛋白质合成在自然强化物和化学强化物操作性反应消退中的作用，人们了解甚少。在本研究中，作者调查了蛋白质合成抑制剂环己酰亚胺（CHX）对甜味奖励操作性反应消退的影响是否取决于重新暴露期的时长。此外，作者还研究了CHX对消退的影响是否能推广到由离散线索诱导的糖精寻求复发。在短时间重新暴露期（5分钟）后注射CHX加速了无强化反应的消退。相比之下，在长时间重新暴露期（30分钟）后注射该药物则部分抑制了消退。由糖精配对离散线索诱导的糖精寻求恢复并未因先前使用CHX治疗而改变。总之，本研究结果表明：（i）蛋白质合成抑制剂CHX可改变大鼠对甜味奖励的操作性反应消退；（ii）CHX对消退的影响关键取决于重新暴露/消退期的时长，且不能推广到由离散线索诱导的糖精寻求复发。
