鉴定肾脏中的Cd36作为血压和高血压风险的决定因素。
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
作者信息
Pravenec Michal, Churchill Paul C, Churchill Monique C, Viklicky Ondrej, Kazdova Ludmila, Aitman Timothy J, Petretto Enrico, Hubner Norbert, Wallace Caroline A, Zimdahl Heike, Zidek Vaclav, Landa Vladimir, Dunbar Joseph, Bidani Anil, Griffin Karen, Qi Nathan, Maxova Martina, Kren Vladimir, Mlejnek Petr, Wang Jiaming, Kurtz Theodore W
机构信息
Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.
出版信息
Nat Genet. 2008 Aug;40(8):952-4. doi: 10.1038/ng.164. Epub 2008 Jun 29.
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
为了鉴定影响高血压风险的肾脏表达基因，我们将肾脏的表达定量性状位点（QTL）分析与来自自发性高血压大鼠（SHR）的重组近交系中肾脏表达谱和血压的全基因组关联分析相结合。该策略，连同对SHR祖系、转基因和近交系进行的肾移植研究，确定了编码脂肪酸转运蛋白的Cd36在肾脏中的表达缺陷是自发性高血压的一个遗传决定风险因素。
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