德国一组免疫功能正常患者的原发性中枢神经系统淋巴瘤与HLA I类和II类等位基因
Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients.
作者信息
Kurzwelly Delia, Müller Claudia A, Korfel Agnieszka, Thiel Eckhard, Linnebank Michael, Weller Michael, Herrlinger Ulrich
机构信息
Clinical Neurooncology Unit, Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
出版信息
J Neurooncol. 2008 Oct;90(1):53-5. doi: 10.1007/s11060-008-9630-5. Epub 2008 Jun 28.
Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.
人类白细胞抗原（HLA）参与对感染的免疫反应调节以及恶性转化过程。若干HLA等位基因与免疫性疾病或恶性疾病相关。本研究的目的是评估HLA I类和II类等位基因与免疫功能正常患者的原发性中枢神经系统淋巴瘤（PCNSL）之间的潜在关联。因此，我们分析了82例PCNSL患者的特定HLA - A、HLA - B和HLA - DRB1等位基因，并将数据与327名人群对照的数据进行比较。使用Pearson卡方检验未发现这两组之间存在显著差异。这些数据不支持HLA等位基因在PCNSL发病机制中起主要作用这一假说。
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