泰国非霍奇金淋巴瘤患者HLA II类等位基因的初步研究。

A preliminary study of HLA class II alleles in Thai patients with non Hodgkin's lymphoma.

作者信息

Nathalang O, Tatsumi N, Hino M, Yamane T, Prayoonwiwat W, Suwanasophon C, Sriphaisal T

机构信息

Department of Pathology, Pramongkutklao College of Medicine, Bangkok, Thailand.

出版信息

Osaka City Med J. 1997 Dec;43(2):253-8.

PMID:9540346

Abstract

The HLA class II alleles were analyzed by the PCR-SSP technique in the DNA samples obtained from 27 Thai patients with non Hodgkin's lymphoma (NHL). It was found that (1) the incidence of HLA-DRB115 and HLA-DRB109 was slightly decreased (P > 0.05). On the other hand, the incidence of HLA-DQB1 alleles was the same as control. However, further study is suggested in order to conclude the close relationship between the presence of certain HLA class II alleles and susceptibility to NHL in Thai patients.

摘要

采用聚合酶链反应-序列特异性引物（PCR-SSP）技术，对27例泰国非霍奇金淋巴瘤（NHL）患者的DNA样本进行了HLA-II类等位基因分析。结果发现：（1）HLA-DRB115和HLA-DRB109的发生率略有下降（P>0.05）。另一方面，HLA-DQB1等位基因的发生率与对照组相同。然而，为了得出某些HLA-II类等位基因的存在与泰国患者对NHL易感性之间的密切关系，建议进一步研究。