Dijke I E, Weimar W, Baan C C
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Transplant Proc. 2008 Jun;40(5):1249-52. doi: 10.1016/j.transproceed.2008.04.004.
The role of regulatory T cells in the induction and maintenance of transplant tolerance has been widely investigated in experimental animal models. Their involvement in the regulation of allogeneic immune reactivity in immunosuppressed organ transplant patients, however, remains unclear. Measurements of regulatory T cells after clinical organ transplantation may contribute to understanding their role in anti-donor immune responses. Several studies have investigated the frequency and/or immune regulatory function of peripheral regulatory T-cell populations, such as, the CD4+CD25+ regulatory T cells or the CD8+CD28- suppressor T cells, in clinically stable organ transplant patients and patients with acute or chronic rejection. This review summarizes these studies and discusses the correlations found between the number and function of regulatory T cells and the immunological state of the patient. This knowledge is warranted for a better understanding of the control of allogeneic immune responses by regulatory T cells. Subsequently, monitoring regulatory T cells may help us to identify patients in whom the anti-donor reactivity is actively suppressed.
调节性T细胞在诱导和维持移植耐受中的作用已在实验动物模型中得到广泛研究。然而，它们在免疫抑制器官移植患者同种异体免疫反应调节中的作用仍不清楚。临床器官移植后调节性T细胞的检测可能有助于了解它们在抗供体免疫反应中的作用。几项研究调查了临床稳定的器官移植患者以及急性或慢性排斥反应患者外周调节性T细胞群体的频率和/或免疫调节功能，如CD4+CD25+调节性T细胞或CD8+CD28-抑制性T细胞。本综述总结了这些研究，并讨论了调节性T细胞的数量和功能与患者免疫状态之间的相关性。这些知识对于更好地理解调节性T细胞对同种异体免疫反应的控制是必要的。随后，监测调节性T细胞可能有助于我们识别抗供体反应被积极抑制的患者。
