[Antipyretic system in humans].

The elevation of body temperature during fever reaction and endogenous antipyretic effect reflects the existing balance between 2 components directed to the maximal positive use of the fever effects and simultaneous prevention of their side effects. The mechanisms involved in the control of balance between factors known as the fever triggers and endogenous antipyretic factors. The possible mechanisms of action of various endogenous antipyretic system components (glucocorticoids, neuropeptides, cytokines etc.) capable to regulate the duration and quantity of fever reaction are discussed in this review.