汉防己甲素海藻酸钙缓释凝胶微丸的制备
[Preparation of tetrandrine alginate calcium sustained release gel pellets].
作者信息
Ma Yan, Li Wei-zhong, Chen Da-wei
机构信息
College of Chinese Traditional Medicine, Guangzhou Universtiy of Chinese Medicine, Guangzhou 510405, China.
出版信息
Zhong Yao Cai. 2008 Jan;31(1):131-4.
OBJECTIVE
To prepare tetrandrine alginate calcium sustained release gel pellets twice daily with Eudragit RS 30D and Eudragit RL 30D.
METHODS
The sustained release gel pellets were prepared by fluid bed technique and release in vitro was selected as the evaluate index. The formulation was optimized by full design test based on the studies of coating factors.
RESULTS
The optimal coating formulation was shown at the ratio of Eudragit RS 30D and Eudragit RL 30D to 5:1, the loading weight of polymers of 45%, the plasticizer concentration of 20% and 35% talcum powder.
CONCLUSION
The perfect sustained release of tetrandrine pellets can be obtained by adjusting the ratio of Eudragit RS 30D and Eudragit RL 30D and the loading weight of polymers.
目的
采用Eudragit RS 30D和Eudragit RL 30D制备粉防己碱海藻酸钙每日两次缓释凝胶微丸。
方法
采用流化床技术制备缓释凝胶微丸，选择体外释放作为评价指标。在包衣因素研究的基础上，通过全设计试验优化处方。
结果
最佳包衣处方为Eudragit RS 30D与Eudragit RL 30D比例为5:1，聚合物载药量为45%，增塑剂浓度为20%，滑石粉为35%。
结论
通过调节Eudragit RS 30D与Eudragit RL 30D的比例和聚合物载药量，可实现粉防己碱微丸的完美缓释。
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