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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.
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Highly conserved beta16/beta17 beta-hairpin structure in human immunodeficiency virus type 1 YU2 gp120 is critical for CCR5 binding.
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CCR5 Inhibitors and HIV-1 Infection.
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Perspectives towards antiviral drug discovery against Ebola virus.
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Opportunities for therapeutic antibodies directed at G-protein-coupled receptors.
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Structural Analysis of Chemokine Receptor-Ligand Interactions.
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C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection.
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On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets.
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Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
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HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry.
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Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.
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Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652.
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GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors.
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