有或无酒精使用障碍病史的抑郁症患者及健康对照者的5-羟色胺能反应。
Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.
作者信息
Sher Leo, Stanley Barbara H, Cooper Thomas B, Malone Kevin M, Mann J John, Oquendo Maria A
机构信息
Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA.
出版信息
Eur Neuropsychopharmacol. 2008 Sep;18(9):692-9. doi: 10.1016/j.euroneuro.2008.05.005. Epub 2008 Jun 30.
Dysfunction of serotonergic neurotransmission has been implicated in the etiopathogenesis of major depression (MDD) and alcohol use disorders (AUD). To compare serotonin function in MDD with co-occurring AUD (MDD/AUD), MDD without co-occurring AUD (MDD only) and healthy controls (HC) we sought to study differences in prolactin responses to fenfluramine administration in patients with MDD/AUD, patients with MDD only and HC. In all, 169 subjects (62 MDD/AUD, 75 MDD only, and 32 HC) were entered into the study. Controlling for gender, prolactin responses were lower in the MDD/AUD group compared to the MDD only or the HC group. Controlling for gender and aggression, prolactin responses in the MDD/AUD group remained significantly lower compared to the HC group but the difference between the MDD/AUD and the MDD only groups disappeared. The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group.
血清素能神经传递功能障碍与重度抑郁症（MDD）和酒精使用障碍（AUD）的病因发病机制有关。为了比较共病AUD的MDD（MDD/AUD）、不伴有共病AUD的MDD（仅MDD）和健康对照（HC）的血清素功能，我们试图研究MDD/AUD患者、仅MDD患者和HC对芬氟拉明给药的催乳素反应差异。共有169名受试者（62名MDD/AUD、75名仅MDD和32名HC）参与了这项研究。在控制性别后，MDD/AUD组的催乳素反应低于仅MDD组或HC组。在控制性别和攻击性后，MDD/AUD组的催乳素反应仍显著低于HC组，但MDD/AUD组与仅MDD组之间的差异消失。MDD/AUD组和仅MDD组之间催乳素反应的差异可归因于MDD/AUD组的攻击性得分高于MDD组。
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