Determination of the GSTM1 gene deletion frequency in Parkinson's disease by allele specific PCR.
作者信息
Stroombergen M C, Waring R H, Bennett P, Williams A C
机构信息
Department of Biochemistry, University of Birmingham, Birmingham, U.K.
出版信息
Parkinsonism Relat Disord. 1996 Jul;2(3):151-4. doi: 10.1016/1353-8020(96)00014-4.
PMID:18591034
Abstract
We have examined the occurrence of GSTM1 null, one of the glutathione S-transferase mu genes, in a control and a Parkinson's disease group. By using the polymerase chain reaction (PCR) we found 67% of non-expressors compared with 51% in a control group (chi(1)(2) = 5.535; p < 0.025). These results suggest that a deletion of the GSTM1 gene may be associated with a susceptibility to Parkinson's disease.
摘要
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