Weikang Chen, Jie Li, Likang Lan, Weiwen Qiu, Liping Lu
Department of Neurology, Lishui People's Hospital (the 6th affiliated hospital of Wenzhou medical university) Zhejiang Lishui 323000 PR China.
Open Med (Wars). 2016 Dec 22;11(1):578-583. doi: 10.1515/med-2016-0094. eCollection 2016.
The aim of this meta-analysis was to evaluate whether there was an association between glutathione S-transferase M1(GSTM1)gene polymorphism and Parkinson's disease (PD) susceptibility by pooling published data. We performed comprehensive electronic database search for articles published between February12,2015 and April30 2016. The published case-control or cohort studies related to GSTM1 gene polymorphism and Parkinson's disease susceptibility were screened, reviewed, and included in this meta-analysis. The correlation between GSTM1 gene polymorphism and PD susceptibility was expressed by odds ratio (OR) and its corresponding 95% confidence interval (95%CI). Publication bias was evaluated by Begg's funnel plot and Egger's line regression test. All analysis was done by stata11.0 software. After searching the PubMed, EMBASE, and CNKI databases, seventeen case-control studies with 3,538 PD and 5,180 controls were included in the final meta-analysis. The data was pooled by a fixed-effect model for lack of statistical heterogeneity across the studies; the results showed GSTM1 null expression can significant increase the susceptibility of PD (OR=1.11, 95% CI:1.01-1.21, P<0.05). Subgroup analysis indicated GSTM1 gene polymorphism was associated with PD susceptibility in the Caucasian ethnic group (OR=1.15, 95% CI:1.05-1.27, P<0.05) but not in the Asian ethnic group (OR=0.89, 95% CI:0.70-1.12, P>0.05). Begg's funnel plot and Egger's line regression test showed no significant publication bias. Based on the present evidence, GSTM1 null expression can significant increase the susceptibility of PD in persons of Caucasian ethnicity.
本荟萃分析的目的是通过汇总已发表的数据，评估谷胱甘肽S-转移酶M1（GSTM1）基因多态性与帕金森病（PD）易感性之间是否存在关联。我们对2015年2月12日至2016年4月30日期间发表的文章进行了全面的电子数据库检索。筛选、审查了与GSTM1基因多态性和帕金森病易感性相关的已发表病例对照或队列研究，并将其纳入本荟萃分析。GSTM1基因多态性与PD易感性之间的相关性用比值比（OR）及其相应的95%置信区间（95%CI）表示。采用Begg漏斗图和Egger线性回归检验评估发表偏倚。所有分析均使用stata11.0软件完成。在检索PubMed、EMBASE和CNKI数据库后，最终的荟萃分析纳入了17项病例对照研究，其中包括3538例PD患者和5180例对照。由于各研究之间缺乏统计学异质性，因此采用固定效应模型对数据进行合并；结果显示，GSTM1基因无效表达可显著增加PD易感性（OR=1.11，95%CI：1.01-1.21，P<0.05）。亚组分析表明，GSTM1基因多态性与白种人种族的PD易感性相关（OR=1.15，95%CI：1.05-1.27，P<0.05），而与亚洲种族无关（OR=0.89，95%CI：0.70-1.12，P>0.05）。Begg漏斗图和Egger线性回归检验均未显示出明显的发表偏倚。基于现有证据，GSTM1基因无效表达可显著增加白种人患PD的易感性。
