以3-羟基吗啡喃（3-HM）为起始原料简洁合成二甲基吗啡烷（DF）。
Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).
作者信息
Kim Jong Yup, Kim Hyoung-Chun, Kim Jeongmin, Lee Jinhwa
机构信息
Small Molecule Group, Central Research Institute, Green Cross Corporation, Yongin, Korea.
出版信息
Chem Pharm Bull (Tokyo). 2008 Jul;56(7):985-7. doi: 10.1248/cpb.56.985.
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.
地美吗啡（DF）已知具有神经保护特性。虽然这种有前景的化合物值得进一步进行生物学评估，但自村上小组在1972年公布合成方法以来，合成方法并未得到改进。本文公开了一种从市售的3-羟基吗啡喃（3-HM）简洁合成DF的方法。通过采用类似的方法，也有效地制备了其他吗啡喃类似物。
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