一例通过通用细菌聚合酶链反应检测确诊的犬链球菌性脑膜脑炎

A case of canine streptococcal meningoencephalitis diagnosed using universal bacterial polymerase chain reaction assay.

作者信息

Messer Jeannette S, Wagner Susan O, Baumwart Ryan D, Colitz Carmen M

机构信息

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.

出版信息

J Am Anim Hosp Assoc. 2008 Jul-Aug;44(4):205-9. doi: 10.5326/0440205.

DOI:10.5326/0440205

PMID:18593857

Abstract

A 3-year-old, spayed female, mixed-breed dog was evaluated for acute, progressive neurological disease. Analysis of cerebrospinal fluid (CSF) showed neutrophilic pleocytosis. The dog later developed liver disease, thrombocytopenia, and anemia that were presumably secondary to ceftriaxone administration. Bacterial cultures of blood, urine, and CSF were negative. However, a universal bacterial polymerase chain reaction assay of CSF identified deoxyribonucleic acid from Streptococcus spp. The dog recovered with therapy for streptococcal encephalitis.

摘要

对一只3岁已绝育的雌性混血犬进行了急性进行性神经疾病评估。脑脊液（CSF）分析显示嗜中性粒细胞增多。该犬随后出现肝病、血小板减少症和贫血，推测是头孢曲松给药的继发反应。血液、尿液和脑脊液的细菌培养均为阴性。然而，脑脊液的通用细菌聚合酶链反应检测鉴定出了链球菌属的脱氧核糖核酸。这只犬经链球菌性脑炎治疗后康复。