Imura Kosuke, Sato Iwao
Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, Japan.
Ann Anat. 2008;190(4):324-8. doi: 10.1016/j.aanat.2008.04.003. Epub 2008 May 27.
Tenascin-X (Tn-X) belongs to the tenascin family of glycoproteins and is clearly associated with the human connective tissue disorder Ehlers-Danlos syndrome. Recently, human single nucleotide polymorphism analyses showed that Tn-X is associated with schizophrenia. Tn-X-related central nervous system (CNS) disorder has been reported in recent years. However, details of Tn-X localization are not clear in the adult cerebral cortex and its meninges. Using immunohistochemical techniques, we found novel localizations of Tn-X in the leptomeningeal trabecula (TB) of adult mice and in the connective tissue of the choroid plexus (CP) in the brains of mice. Subsequent immunohistochemical studies showed complementary localization of Tn-X in the leptomeninges and CP. Localization of tenascin-C was not detected in the leptomeningeal TB or in the connective tissue of the CP. These results might provide insight into the role of Tn-X in the pathogenesis of disorders in the CNS.
腱生蛋白-X（Tn-X）属于腱生蛋白家族糖蛋白，且与人类结缔组织疾病埃勒斯-当洛综合征密切相关。最近，人类单核苷酸多态性分析表明，Tn-X与精神分裂症有关。近年来，已有关于Tn-X相关中枢神经系统（CNS）疾病的报道。然而，在成人大脑皮层及其脑膜中，Tn-X的定位细节尚不清楚。利用免疫组化技术，我们在成年小鼠的软脑膜小梁（TB）以及小鼠大脑脉络丛（CP）的结缔组织中发现了Tn-X的新定位。随后的免疫组化研究显示，Tn-X在软脑膜和脉络丛中呈互补定位。在软脑膜TB或脉络丛的结缔组织中未检测到腱生蛋白-C的定位。这些结果可能有助于深入了解Tn-X在中枢神经系统疾病发病机制中的作用。
