Rosskothen Nicole, Hirschmüller-Ohmes Ingeborg, Illing Robert-Benjamin
Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany.
Neuroreport. 2008 Jul 16;19(11):1091-3. doi: 10.1097/WNR.0b013e328303bbeb.
Acoustical or intracochlear stimulation may induce expression of the immediate early gene product c-Fos in neurons throughout the auditory brainstem. Attempting to estimate its consequences, we sought to determine if c-Fos expression occurs in neurons that also contain c-Jun p39 with which it could form the heterodimeric transcription factor AP-1 to activate a large number of genes, among them several involved in neuroplastic remodeling. Following intracochlear stimulation, c-Fos and c-Jun were found to be colocalized in nuclei of many neurons at all levels of the subcortical auditory system. We conclude that stimulation triggers Fos-Jun dimerization, causing cascades of gene expression that potentially culminate in structural changes of neurons affected by the specific pattern of activity imposed on the neuronal system.
听觉或耳蜗内刺激可诱导整个听觉脑干神经元中即早基因产物c-Fos的表达。为了评估其后果，我们试图确定c-Fos表达是否发生在同时含有c-Jun p39的神经元中，c-Fos可与之形成异二聚体转录因子AP-1，从而激活大量基因，其中包括几个参与神经可塑性重塑的基因。耳蜗内刺激后，发现c-Fos和c-Jun共定位于皮层下听觉系统各级许多神经元的细胞核中。我们得出结论，刺激触发Fos-Jun二聚化，引发基因表达级联反应，最终可能导致受施加于神经元系统的特定活动模式影响的神经元发生结构变化。
