Gin T, Yau G, Jong W, Tan P, Leung R K, Chan K
Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Br J Anaesth. 1991 Jul;67(1):49-53. doi: 10.1093/bja/67.1.49.
We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg-1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4-53.3) ml min-1 kg-1, apparent volume of distribution at steady state 5.10 (2.46-6.61) litre kg-1 and mean residence time 161 (52.3-251) min; values for the post-partum group were 33.8 (21.5-47.2) ml min-1 kg-1, 5.17 (3.47-8.09) litre kg-1 and 163 (92.3-238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62-0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28-2.29%) compared with umbilical plasma (2.08-3.88%) (P less than 0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range 0.05-0.11 micrograms ml-1 at 4 h.
我们比较了8例剖宫产患者静脉注射2mg/kg丙泊酚后的药代动力学参数，并与8例接受小切口绝育术的产后患者进行了对比。剖宫产组的总体清除率（中位数）为31.5（范围24.4 - 53.3）ml·min⁻¹·kg⁻¹，稳态分布容积为5.10（2.46 - 6.61）L·kg⁻¹，平均驻留时间为161（52.3 - 251）分钟；产后组的相应值分别为33.8（21.5 - 47.2）ml·min⁻¹·kg⁻¹、5.17（3.47 - 8.09）L·kg⁻¹和163（92.3 - 238）分钟。分娩时丙泊酚脐静脉与母体静脉浓度比的95%置信区间为0.62 - 0.86。血浆蛋白结合研究表明，母体血浆中未结合的丙泊酚较少（1.28 - 2.29%），而脐血浆中为2.08 - 3.88%（P＜0.01）。丙泊酚在新生儿体内的浓度在2小时时高于母体，在4小时时为0.05 - 0.11μg/ml。
