Camicioli Richard M, Wieler Marguerite, de Frias Cindy M, Martin W R Wayne
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.
Neurosci Lett. 2008 Aug 15;441(1):77-80. doi: 10.1016/j.neulet.2008.06.004. Epub 2008 Jun 6.
While Parkinson's disease (PD) is associated with motor slowing, less attention has been paid to variability in performance on motor and cognitive tasks. To examine reaction time latencies and intraindividual variability in untreated patients with PD compared to healthy controls. Twenty-nine (19 men/10 women) patients with untreated PD and 16 controls (8 men/8 women) were examined using measures of simple reaction time (SRT) and choice reaction time (CRT) in addition to cognitive measures of executive function (Trail Making Test; adaptive digit ordering). Latencies and intraindividual variability were compared between groups. Partial correlation coefficients, adjusting for age, sex and education were used to examine the relationship between RT measures and motor or cognitive measures. Patients and controls did not differ with respect to age or sex distribution. Education and cognitive status differed between groups, but no subject was demented or clinically depressed. After adjusting for age, sex and education, significant group differences were found in latencies (2-choice RT and 8-choice RT) and intraindividual variability scores (all CRT conditions). Latencies did not differ significantly after adjusting for finger tapping rate. In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD.
虽然帕金森病（PD）与运动迟缓相关，但对运动和认知任务表现的变异性关注较少。为了研究未经治疗的PD患者与健康对照相比的反应时间延迟和个体内变异性。对29名（19名男性/10名女性）未经治疗的PD患者和16名对照（8名男性/8名女性）进行了检查，除了执行功能的认知测量（连线测验；自适应数字排序）外，还使用了简单反应时间（SRT）和选择反应时间（CRT）测量。比较了两组之间的延迟和个体内变异性。使用调整年龄、性别和教育程度后的偏相关系数来检查反应时间测量与运动或认知测量之间的关系。患者和对照在年龄或性别分布方面没有差异。两组之间的教育程度和认知状态不同，但没有受试者患有痴呆或临床抑郁症。在调整年龄、性别和教育程度后，发现两组在延迟（2选反应时间和8选反应时间）和个体内变异性得分（所有CRT条件）方面存在显著差异。在调整手指敲击速率后，延迟没有显著差异。在PD组中，运动测量和执行测量均与任何反应时间测量均无显著相关性。我们得出结论，未经治疗的PD患者的CRT个体内变异性和延迟增加。
