Tang Bo, Cheng Gang, Gu Jian-Chun, Xu Cai-Hong
Shenyang Pharmaceutical University, Shenyang City 110016, Liaoning Province, People's Republic of China.
Drug Discov Today. 2008 Jul;13(13-14):606-12. doi: 10.1016/j.drudis.2008.04.006. Epub 2008 Jun 3.
Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SEDDS (S-SEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article gives an overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms. Finally, the existing problems and the possible future research directions in this field are pointed out.
大约40%的新化学实体表现出较差的水溶性，由于其生物利用度低，给现代药物递送系统带来了重大挑战。自乳化药物递送系统（SEDDS）通常用于提高疏水性药物的生物利用度。然而，传统的SEDDS大多以液体形式制备，这可能会产生一些缺点。因此，通过将液体/半固体自乳化（SE）成分固化成粉末制备的固体SEDDS（S-SEDDS）受到了欢迎。本文概述了S-SEDDS研究的最新进展，特别是相关的固化技术和固体SE剂型的发展。最后，指出了该领域存在的问题和未来可能的研究方向。
