E3泛素连接酶的HECT家族：癌症发展中的多个参与者
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
作者信息
Bernassola Francesca, Karin Michael, Ciechanover Aaron, Melino Gerry
机构信息
Department of Experimental Medicine and Biochemical Sciences, Biochemistry IDI-IRCCS Laboratory, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
出版信息
Cancer Cell. 2008 Jul 8;14(1):10-21. doi: 10.1016/j.ccr.2008.06.001.
The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
与E6-AP羧基末端（HECT）型E3泛素连接酶参与肿瘤发生相关的关键信号通路，目前是一个深入研究且备受广泛科学关注的领域。本综述重点介绍了近期关于HECT型E3泛素连接酶催化关键肿瘤抑制分子泛素化降解的发现。通过描绘其蛋白质靶点，我们旨在将HECT型E3泛素连接酶的底物特异性与其对肿瘤发生的作用联系起来。此外，我们还讨论了通过开发小分子抑制剂靶向HECT E3泛素连接酶作为抗癌治疗策略的相关性。
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