Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
J Cell Biochem. 2010 Jun 1;110(3):554-63. doi: 10.1002/jcb.22586.
The homologous to the E6-associated protein carboxyl terminus (HECT) domain E3 ubiquitin ligase Smurf1 is the first E3 ligase to be implicated in regulating bone cell function. The involvement of Smurf1 in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review highlights recent works exploring Smurf-regulated biological processes in bone cells and highlights recent discoveries surrounding the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Moreover, we discuss the relevance of targeting the HECT E3s through the development of small-molecule inhibitors as an anticancer therapeutic strategy.
同源物到 E6 相关蛋白羧基末端 (HECT) 域 E3 泛素连接酶 Smurf1 是第一个被牵连到调节骨细胞功能的 E3 连接酶。Smurf1 参与多种信号通路和病理条件目前是一个广泛的科学兴趣领域。这篇综述强调了最近探索 Smurf1 在骨细胞中调节的生物学过程的工作，并强调了最近围绕调节其催化活性和底物识别能力的调控机制的发现。此外，我们还讨论了通过开发小分子抑制剂作为抗癌治疗策略来靶向 HECT E3 的相关性。
