英夫利昔单抗在炎症性肠病中的作用机制：一种抗炎多面手。
Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker.
作者信息
Danese S
机构信息
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy.
出版信息
Dig Liver Dis. 2008 Jul;40 Suppl 2:S225-8. doi: 10.1016/S1590-8658(08)60530-7.
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a central role in mucosal inflammation and is a key mediator in the inflammatory cascade in both Crohn's disease (CD) and ulcerative colitis (UC). Infliximab, a monoclonal antibody against TNF-alpha has been proved highly effective in the clinical management of both forms of IBD. Aim of this paper is to review the mechanisms of action of infliximab in IBD.
促炎细胞因子肿瘤坏死因子-α（TNF-α）在黏膜炎症中起核心作用，并且是克罗恩病（CD）和溃疡性结肠炎（UC）炎症级联反应中的关键介质。英夫利昔单抗是一种抗TNF-α单克隆抗体，已被证实在两种炎症性肠病（IBD）的临床治疗中非常有效。本文旨在综述英夫利昔单抗在IBD中的作用机制。
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