Zacharis Constantinos K, Tzanavaras Paraskevas D
Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124 Thessaloniki, Greece.
J Pharm Biomed Anal. 2008 Nov 4;48(3):483-96. doi: 10.1016/j.jpba.2008.05.028. Epub 2008 Jul 2.
Bisphosphonates is a class of chemical compounds finding extensive medical applications against bone disorders including osteoporosis, Pagets' disease, etc. Non-N-containing members include etidronate, clodronate and tiludronate, while N-containing bisphosphonates include active pharmaceutical compounds such as pamidronate, neridronate, olpadronate, alendronate, ibandronate, risedronate and zoledronate. The present study covers 20 years of analytical research on this group of compounds, focusing on bioanalytical and pharmaceutical QC applications. A wide range of analytical techniques is presented and critically discussed including among others liquid and gas phase separations, electrophoretic, electroanalytical, automated and enzymatic approaches.
双膦酸盐是一类化合物，在治疗包括骨质疏松症、佩吉特氏病等骨骼疾病方面有广泛的医学应用。不含氮的成员包括依替膦酸、氯膦酸和替鲁膦酸，而含氮双膦酸盐包括活性药物化合物，如帕米膦酸、奈立膦酸、奥帕膦酸、阿仑膦酸、伊班膦酸、利塞膦酸和唑来膦酸。本研究涵盖了对这组化合物20年的分析研究，重点是生物分析和药物质量控制应用。介绍并批判性地讨论了广泛的分析技术，包括液相和气相分离、电泳、电分析、自动化和酶促方法等。
