Suppr超能文献

芬兰学童卡介苗再接种计划的评估

Evaluation of the BCG revaccination programme of schoolchildren in Finland.

作者信息

Tala-Heikkila M, Nurmela T, Tala E, Tuominen J

机构信息

Department of Paediatrics, University Central Hospital, Turku, Finland.

出版信息

Bull Int Union Tuberc Lung Dis. 1991 Mar;66(1):57-9.

PMID:1859944
Abstract

OBJECTIVE

To evaluate the need for the BCG revaccination programme of schoolchildren in Finland.

DESIGN

Investigating tuberculin sensitivity using the standard WHO Mantoux test and developing a model to estimate the risk of discontinuation, assuming that the annual incidence of tuberculosis within ten years after revaccination will remain at its present level; that the revaccination rate will be 2, 6 or 20%; and that the degree of protection will be 10, 20, 40 or 80%.

SETTING AND PARTICIPANTS

Urban and rural schoolchildren--3,346 vaccinated with Copenhagen and 655 with Glaxo BCG vaccine at birth.

RESULTS OF DATA ANALYSIS

The annual incidence of tuberculosis was 4.2 per 100,000 in the age-group 15-24 years. BCG revaccination was given formerly to 20% of the age cohort but nowadays only 6% or 2% meet the criteria after receiving either Copenhagen or Glaxo BCG at birth. After discontinuation the expected increase of tuberculosis in the age-group 15-24 years is predicted to fall within the limits of 0.1-24 cases per year. If 2% are left without revaccination the increase will be 0.1-2.4 cases.

CONCLUSIONS

Due to the low annual incidence of tuberculosis in adolescents and to the small risk of increase the BCG revaccination programme has been discontinued from 1990 onwards.

摘要

目的

评估芬兰学童卡介苗复种计划的必要性。

设计

采用世界卫生组织标准曼托试验调查结核菌素敏感性,并建立一个模型来估计复种中断的风险,假设复种后十年内结核病的年发病率将维持在当前水平;复种率分别为2%、6%或20%;保护程度分别为10%、20%、40%或80%。

地点和参与者

城乡学童——3346名出生时接种哥本哈根卡介苗,655名接种葛兰素史克卡介苗。

数据分析结果

15 - 24岁年龄组的结核病年发病率为每10万人4.2例。以前该年龄队列中有20%接受过卡介苗复种,但如今出生时接种哥本哈根或葛兰素史克卡介苗后,只有6%或2%符合复种标准。复种中断后,预计15 - 24岁年龄组结核病增加的病例数每年将在0.1 - 24例之间。如果有2%的人未进行复种,增加的病例数将为0.1 - 2.4例。

结论

由于青少年结核病年发病率较低,且增加的风险较小,自1990年起已停止卡介苗复种计划。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验