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T cell response in acquired protective immunity to Mycobacterium tuberculosis infection.

作者信息

Orme I M, Lee B Y, Appelberg R, Miller E S, Chi D L, Griffin J P, Roberts A D

机构信息

Department of Microbiology, Colorado State University, Fort Collins 80523.

出版信息

Bull Int Union Tuberc Lung Dis. 1991 Mar;66(1):7-13.

PMID:1859946
Abstract
摘要

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T cell response in acquired protective immunity to Mycobacterium tuberculosis infection.结核分枝杆菌感染获得性保护性免疫中的T细胞应答。
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2
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Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes.衰老与对结核病的免疫力：老年小鼠易感性增加反映出产生调节性T淋巴细胞的能力下降。
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Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.肿瘤坏死因子基因靶向小鼠肉芽肿形成的结构缺陷是其对气溶胶结核分枝杆菌感染易感性增加的基础，而淋巴毒素无法弥补这一缺陷。
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Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule.缺乏CD44分子的小鼠中性粒细胞流入增加，但对结核病的保护性免疫未受损。
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Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.结核分枝杆菌感染后获得的CD4 T淋巴细胞分泌细胞因子的情况。
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引用本文的文献

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Regulation of human CD4(+) alphabeta T-cell-receptor-positive (TCR(+)) and gammadelta TCR(+) T-cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor beta.白细胞介素-10和转化生长因子β对人CD4(+)αβT细胞受体阳性（TCR(+)）和γδTCR(+)T细胞针对结核分枝杆菌反应的调节
Infect Immun. 1999 Dec;67(12):6461-72. doi: 10.1128/IAI.67.12.6461-6472.1999.
2
Inflammatory response following intranasal infection with Mycobacterium avium complex: role of T-cell subsets and gamma interferon.鸟分枝杆菌复合群鼻内感染后的炎症反应：T细胞亚群和γ干扰素的作用
Infect Immun. 1995 Jun;63(6):2282-7. doi: 10.1128/iai.63.6.2282-2287.1995.