Sarchiapone Marco, Carli Vladimir, Roy Alec, Iacoviello Licia, Cuomo Chiara, Latella Maria Carmela, di Giannantonio Massimo, Janiri Luigi, de Gaetano Monica, Janal Malvin N
Department of Health Sciences, University of Molise, Campobasso, Italy.
Neuropsychobiology. 2008;57(3):139-45. doi: 10.1159/000142361. Epub 2008 Jul 7.
Recent post-mortem studies of suicide victims have implicated brain-derived neurotrophic factor (BDNF) in suicide. Therefore, it was decided to examine the possible role of a gene in the regulation of BDNF activity in relation to suicidal behaviour among depressed patients.
A series of 170 depressed patients were evaluated for their history of suicide attempts and genotyped for the BDNF Val66Met polymorphism (SNP ID: rs6265). Depressed patients who had (n = 97) or had not (n = 73) attempted suicide were compared.
Depressed patients who carried the BDNF Val66Met polymorphism variant (GA + AA) appeared to show a significantly increased risk of suicidal behaviour. The risk of a suicide attempt was also significantly higher among those reporting higher levels of childhood emotional, physical and sexual abuse. Secondary analyses suggested that depression severity was a significant risk factor only in the wild-type BDNF genotype, and that the risk of suicide attempts was more predictable within the wild-type group.
These preliminary data suggest that BDNF may play a role in the suicidal behaviour of depressed patients.
近期对自杀受害者的尸检研究表明，脑源性神经营养因子（BDNF）与自杀有关。因此，本研究旨在探讨一个基因在调节BDNF活性方面与抑郁症患者自杀行为之间的可能作用。
对170例抑郁症患者进行自杀未遂史评估，并对BDNF Val66Met多态性（单核苷酸多态性ID：rs6265）进行基因分型。比较有自杀未遂史（n = 97）和无自杀未遂史（n = 73）的抑郁症患者。
携带BDNF Val66Met多态性变异（GA + AA）的抑郁症患者自杀行为风险显著增加。报告童年期情感、身体和性虐待程度较高的患者自杀未遂风险也显著更高。二次分析表明，抑郁严重程度仅在野生型BDNF基因型中是一个显著的风险因素，并且在野生型组中自杀未遂风险更具可预测性。
这些初步数据表明，BDNF可能在抑郁症患者的自杀行为中起作用。
