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Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala.

作者信息

Lee M A, Paris J M, Cunningham K A

机构信息

Department of Pharmacology, University of Texas Medical Branch, Galveston 77550.

出版信息

Brain Res. 1991 Apr 5;545(1-2):351-4. doi: 10.1016/0006-8993(91)91313-p.

DOI:10.1016/0006-8993(91)91313-p
PMID:1860058
Abstract

We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in gamma-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alterations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.

摘要

相似文献

1
Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala.
Brain Res. 1991 Apr 5;545(1-2):351-4. doi: 10.1016/0006-8993(91)91313-p.
2
Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex.杏仁核点燃诱导同侧梨状皮质离散区域中γ-氨基丁酸免疫反应性神经元的持续减少。
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3
Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala.可卡因与点燃效应会改变杏仁核中央核中II型和III型代谢型谷氨酸受体的敏感性。
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4
Decrease of GABA-immunoreactive neurons in the amygdala after electrical kindling in the rat.
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5
Endogenous GABA release is reduced in the striatum of cocaine-sensitized rats.
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6
The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures.杏仁核点燃对自发及可卡因诱导的运动活动和利多卡因惊厥的影响。
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7
Gamma-aminobutyric acid-immunoreactive neurons in the amygdala of the rat - sex differences and effect of early postnatal castration.
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8
Repeated cocaine injections decrease the function of striatal gamma-aminobutyric acid(A) receptors.
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Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine.腹侧被盖区和杏仁核中 N-甲基-D-天冬氨酸受体刺激在对可卡因行为敏化中的作用。
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10
Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats.γ-乙烯基氨基丁酸，一种γ-氨基丁酸转氨酶的不可逆抑制剂，会改变雄性大鼠对可卡因诱导的敏化作用的获得和表达。
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