Yamazaki Y, Hosono K, Matsuda H, Minami N, Asai M, Nakanishi H
Fermentation Research Institute, AIST, Tsukuba, Ibaraki 305, Japan.
Biotechnol Bioeng. 1991 Dec 5;38(10):1218-22. doi: 10.1002/bit.260381014.
Twelve species of optically active metallocene derivatives having a 4-nitrophenyl group were prepared with horse liver alcohol dehydrogenase- or lipase-catalyzed optical resolution as the key step. The second harmonic generation (SHG) efficiently of these products was measured by the power method using the fundamental light from the Nd:YAG laser. (-)-1- (4-Nitrophenylthio)ethylferrocene (9), (+)-1-(4-nitrophenylthio)ethylruthenocene (16), (+)-1-(4-nitrophenylthio)ethylosmocene (19), (+) -1-(5-nitro-2-pyridylthio)ethylruthenocene (21), and (+) -1-[(4-nitrophenylhydrazono)methyl] -2-methylferrocene (12) showed SHG signals. The highest SHG efficiency was found with (+) -16, being 27 times more intense than the commonly used urea standard.
以马肝醇脱氢酶或脂肪酶催化的光学拆分作为关键步骤，制备了12种具有4-硝基苯基的旋光茂金属衍生物。使用来自Nd:YAG激光器的基频光，通过功率法测量了这些产物的二次谐波产生（SHG）效率。（-）-1-（4-硝基苯硫基）乙基二茂铁（9）、（+）-1-（4-硝基苯硫基）乙基钌茂（16）、（+）-1-（4-硝基苯硫基）乙基锇茂（19）、（+）-1-（5-硝基-2-吡啶硫基）乙基钌茂（21）和（+）-1-[(4-硝基苯腙基)甲基]-2-甲基二茂铁（12）显示出SHG信号。发现（+）-16的SHG效率最高，比常用的尿素标准强27倍。
