Grove Tijana Z, Cortajarena Aitziber L, Regan Lynne
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.
Curr Opin Struct Biol. 2008 Aug;18(4):507-15. doi: 10.1016/j.sbi.2008.05.008. Epub 2008 Jul 23.
Repeat proteins contain tandem arrays of small structural motifs. As a consequence of this architecture, they adopt non-globular, extended structures that present large, highly specific surfaces for ligand binding. Here we discuss recent advances toward understanding the functional role of this unique modular architecture. We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein-ligand interactions.
重复蛋白包含小结构基序的串联阵列。由于这种结构,它们呈现出非球状的伸展结构,为配体结合提供了大的、高度特异性的表面。在这里,我们讨论了在理解这种独特模块化结构的功能作用方面的最新进展。我们展示了天然重复蛋白与多种配体相互作用的具体例子,也展示了设计的重复蛋白 - 配体相互作用的例子。