Min Seiko, Sato Shuichi, Saito Masakazu, Ebihara Hajime, Arai Yoshinori, Ito Koichi
Division of Applied Oral Sciences, Nihon University School of Dentistry, Tokyo, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Dec;106(6):892-5. doi: 10.1016/j.tripleo.2008.04.012. Epub 2008 Jul 7.
A new microfocus computerized tomography (R-mCT) system that quickly produces clear images of the bones of small animals allows the continuous observation of living experimental animals. This study used the new R-mCT system to examine the dynamics of marrow penetration within a titanium cap in rabbit calvarium.
In a rabbit, the calvarium was exposed, and circular grooves were prepared bilaterally. Within the circular groove, the external cortical surface of the skull was perforated mechanically. The rate of penetration was 28% (experiment) or 14% (control). Images of bone augmentation within the titanium cap were taken using R-mCT.
The augmented mineralized tissue increased gradually with repeated resorption and acceleration. The dynamics of bone augmentation did not differ with the penetration rate.
Accurate noninvasive longitudinal monitoring of bone augmentation or response to therapy can now be done in the same living animal by using R-mCT.
一种新型微焦点计算机断层扫描（R-mCT）系统能够快速生成小动物骨骼的清晰图像，从而可以对活体实验动物进行连续观察。本研究使用新型R-mCT系统来检测兔颅骨钛帽内骨髓渗透的动态变化。
在一只兔子身上，暴露颅骨，并在两侧制备圆形凹槽。在圆形凹槽内，用机械方法在颅骨外皮质表面打孔。打孔率为28%（实验组）或14%（对照组）。使用R-mCT拍摄钛帽内骨增量的图像。
随着反复吸收和加速，矿化组织增量逐渐增加。骨增量的动态变化与打孔率无关。
现在通过使用R-mCT，可以在同一只活体动物中对骨增量或治疗反应进行准确的无创纵向监测。
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