Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Turk J Med Sci. 2021 Dec 13;51(6):3115-3125. doi: 10.3906/sag-2011-109.
BACKGROUND/AIM: Guided bone regeneration (GBR) is commonly performed to repair bone defects, and rigid occlusive titanium barriers play a vital role in bone formation in regions with no prior bone tissue. The statin, rosuvastatin (RSV), strongly affects bone apposition when applied locally. Here, we aimed to evaluate the anabolic effects of locally applied RSV with a xenograft placed on rabbit calvaria.
Two rigid occlusive titanium caps were used in 16 rabbits after decorticating the calvarial bone. In the control group, the area under the cap was filled with a xenograft, while in the RSV group, a xenograft in combination with RSV (1 mg) was used. In both groups, at 6 and 12 weeks, new bone, residual graft, soft tissue areas, and histological and radiological bone volume were evaluated.
At 12 weeks, histologically, the RSV group exhibited superior new bone proportion values, and radiologically, new bone and total bone volume in the RSV group were significantly higher than in the control group (p < 0.05); there were no significant differences at 6 weeks (p > 0.05).
According to our results, RSV applied locally under a titanium barrier on an area to be repaired with bone grafts increases new bone and total bone volume.
背景/目的：引导骨再生（GBR）常用于修复骨缺损，刚性封闭钛屏障在无先前骨组织的区域对骨形成起着至关重要的作用。局部应用的他汀类药物瑞舒伐他汀（RSV）强烈影响骨附着。在这里，我们旨在评估局部应用 RSV 与异种移植物在兔颅骨上的协同作用对骨形成的影响。
16 只兔子去皮质化颅骨后使用 2 个刚性封闭钛帽。在对照组中，帽下区域填充异种移植物，而在 RSV 组中，使用异种移植物加 RSV（1mg）。在两组中，在 6 周和 12 周时，评估新骨、残留移植物、软组织区域以及组织学和影像学骨量。
12 周时，组织学上，RSV 组显示出更高的新骨比例值，影像学上，RSV 组的新骨和总骨量明显高于对照组（p<0.05）；6 周时无显著差异（p>0.05）。
根据我们的结果，钛屏障下局部应用 RSV 可增加新骨和总骨量，用于修复骨缺损。
