Montag Christian, Basten Ulrike, Stelzel Christine, Fiebach Christian J, Reuter Martin
Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, D-53111 Bonn, Germany.
Neurosci Lett. 2008 Sep 5;442(1):30-3. doi: 10.1016/j.neulet.2008.06.064. Epub 2008 Jun 27.
Although the brain derived neurotrophic factor (BDNF) has been mainly investigated in the context of depression and anxiety disorders, several studies also suggest an association between BDNF and smoking. BDNF represents a protein which crucially influences several processes in the cell ranging from growth to apoptosis. A functional variant of the BDNF gene - the BDNF Val66Met polymorphism - is one of the main targets in BDNF research because of its influence on BDNF secretion. Recently an association between the 66Met allele and smoking has been reported in a sample of 320 Caucasians. The aim of the present study was to replicate this association in a sample nearly twice as large consisting of N=614 German Caucasian participants. A link between smoking and the BDNF Val66Met polymorphism could not be found in our data.
尽管脑源性神经营养因子（BDNF）主要是在抑郁症和焦虑症的背景下进行研究的，但一些研究也表明BDNF与吸烟之间存在关联。BDNF是一种蛋白质，它对细胞内从生长到凋亡的多个过程都有着至关重要的影响。BDNF基因的一个功能性变体——BDNF Val66Met多态性——因其对BDNF分泌的影响，成为BDNF研究的主要靶点之一。最近，在一个由320名高加索人组成的样本中，报道了66Met等位基因与吸烟之间的关联。本研究的目的是在一个规模几乎是前者两倍的样本（由N = 614名德国高加索参与者组成）中重复这一关联。在我们的数据中未发现吸烟与BDNF Val66Met多态性之间的联系。
