Toyooka Mariko, Kimura Hirohiko, Uematsu Hidemasa, Kawamura Yasutaka, Takeuchi Hiroaki, Itoh Harumi
Department of Radiology, University of Fukui, Fukui 910-1193, Japan.
Clin Imaging. 2008 Jul-Aug;32(4):251-8. doi: 10.1016/j.clinimag.2007.12.006.
Our intent was to clarify the usefulness of proton magnetic resonance spectroscopy (MRS) and perfusion-weighted magnetic resonance imaging (PW-MRI) in the grading of glioma.
Twenty-three consecutive patients with gliomas were investigated by both proton MRS and PW-MRI. For quantitative analysis, the metabolite data of the gliomas were estimated using the LCModel software. Receiver operating characteristic (ROC) curve analyses were also performed to assess which metabolite parameter was optimal for discrimination of glioma grade. From the PW-MRI data, the value of blood volume was measured on the parametric map corresponding to the location of MRS analysis. We then compared tumor blood volume with the amount of choline (Cho).
The mean Cho/creatine (Cre) ratio was useful to discriminate between Grades II and III, and the mean lactate (Lac)/Cre ratio was found to be significantly different between Grades III and IV. ROC curve analysis showed that measurements involving Cho were superior indices for grading glioma compared with blood volume information. Furthermore, the correlation between tumor blood volume and the amount of choline was statistically significant.
MRS may provide valuable information for glioma grading.
我们旨在阐明质子磁共振波谱（MRS）和灌注加权磁共振成像（PW-MRI）在胶质瘤分级中的作用。
连续23例胶质瘤患者接受了质子MRS和PW-MRI检查。进行定量分析时，使用LCModel软件估算胶质瘤的代谢物数据。还进行了受试者操作特征（ROC）曲线分析，以评估哪种代谢物参数最有助于区分胶质瘤级别。根据PW-MRI数据，在与MRS分析位置对应的参数图上测量血容量值。然后我们将肿瘤血容量与胆碱（Cho）含量进行比较。
平均Cho/肌酸（Cre）比值有助于区分II级和III级胶质瘤，且发现平均乳酸（Lac）/Cre比值在III级和IV级之间存在显著差异。ROC曲线分析表明，与血容量信息相比，涉及Cho的测量是胶质瘤分级的更优指标。此外，肿瘤血容量与胆碱含量之间的相关性具有统计学意义。
MRS可为胶质瘤分级提供有价值的信息。
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