Striano Pasquale, Zara Federico, Santorelli Filippo Maria, Striano Salvatore
Department of Neurological Sciences, Federico II University, Napoli, Italy.
J Neurol Sci. 2008 Sep 15;272(1-2):194-5. doi: 10.1016/j.jns.2008.05.015. Epub 2008 Jul 7.
Topiramate has been shown to be highly effective for preventive treatment of migraine and its use has been significantly increased in the last few years. However, around 10% of migraineurs develop a worsening of their symptoms while on topiramate. We report a 33-year-old woman with familial hemiplegic migraine (FHM) who experienced worsening of her symptoms following repeated topiramate intake. Withdrawal of the drug rapidly constantly induced resolution of the symptoms. This is the first report of topiramate-associated worsening symptoms in FHM. It is important to be aware of this phenomenon, as topiramate is worldwide-used drug for migraine treatment.
托吡酯已被证明对偏头痛的预防性治疗非常有效，并且在过去几年中其使用量显著增加。然而，约10%的偏头痛患者在服用托吡酯期间症状会加重。我们报告一名33岁患有家族性偏瘫性偏头痛（FHM）的女性，她在反复服用托吡酯后症状加重。停药后症状迅速持续缓解。这是关于托吡酯与FHM相关症状加重的首例报告。鉴于托吡酯是全球范围内用于治疗偏头痛的药物，了解这一现象很重要。
