成年系统性红斑狼疮患者的抗RO、抗LA、抗RNP抗体与心电图PR间期
Anti-RO anti-LA anti-RNP antibodies and eletrocardiogram's PR interval in adult patients with systemic lupus erythematosus.
作者信息
Costa Militino, Gameiro Silva Marilia Barreto, Silva José Antonio, Skare Thelma L
机构信息
Servico de Reumatologia do Hospital Universitario Evangelico de Curitiba-PR Brasil.
出版信息
Acta Reumatol Port. 2008 Apr-Jun;33(2):173-6.
BACKGROUND
Children born from mothers with anti-Ro La or RNP autoantibodies may develop neonatal lupus. One of the manifestations of neonatal lupus is congenital atrio ventricular block.
OBJECTIVE
To study EKG PR interval in adult systemic lupus erythematosus (SLE) patients with anti-Ro anti-La and anti-RNP autoantibodies.
METHODS
PR intervals and the presence of anti-Ro La and RNP antibodies were studied in 61 SLE patients and compared with 61 controls.
RESULTS
36.6% of SLE patients were anti-Ro positive 20% were anti-La and 22.9% were anti-RNP positive. All studied PR intervals were within normal limits (upper limit of 0.2 sec). We did not find any association between PR interval length and the presence of anti-Ro (p=0.54) anti-La (p=0.45) or anti-RNP autoantibodies (p=0.36).
CONCLUSION
The presence of anti-Ro La and RNP autoantibodies does not influence PR interval in adult SLE patients.
背景
母亲患有抗Ro、La或RNP自身抗体的新生儿可能会患新生儿狼疮。新生儿狼疮的表现之一是先天性房室传导阻滞。
目的
研究患有抗Ro、抗La和抗RNP自身抗体的成年系统性红斑狼疮（SLE）患者的心电图PR间期。
方法
对61例SLE患者的PR间期以及抗Ro、La和RNP抗体的存在情况进行研究，并与61例对照进行比较。
结果
36.6%的SLE患者抗Ro阳性，20%抗La阳性，22.9%抗RNP阳性。所有研究的PR间期均在正常范围内（上限为0.2秒）。我们未发现PR间期长度与抗Ro（p = 0.54）、抗La（p = 0.45）或抗RNP自身抗体的存在之间存在任何关联（p = 0.36）。
结论
抗Ro、La和RNP自身抗体的存在不会影响成年SLE患者的PR间期。
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