微生物穿越血脑屏障的机制。
Mechanisms of microbial traversal of the blood-brain barrier.
作者信息
Kim Kwang Sik
机构信息
Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3157, Baltimore, Maryland 21287, USA.
出版信息
Nat Rev Microbiol. 2008 Aug;6(8):625-34. doi: 10.1038/nrmicro1952. Epub 2008 Jul 7.
Abstract
Central nervous system (CNS) infections continue to be an important cause of morbidity and mortality. Microbial invasion and traversal of the blood-brain barrier is a prerequisite for CNS infections. Pathogens can cross the blood-brain barrier transcellularly, paracellularly and/or in infected phagocytes (the so-called Trojan-horse mechanism). Consequently, pathogens can cause blood-brain barrier dysfunction, including increased permeability, pleocytosis and encephalopathy. A more complete understanding of the microbial-host interactions that are involved in microbial traversal of the blood-brain barrier and the associated barrier dysfunction should help to develop new strategies to prevent CNS infections.
摘要
中枢神经系统（CNS）感染仍然是发病和死亡的重要原因。微生物侵入并穿越血脑屏障是中枢神经系统感染的先决条件。病原体可以通过跨细胞、细胞旁和/或在被感染的吞噬细胞中（所谓的特洛伊木马机制）穿过血脑屏障。因此，病原体可导致血脑屏障功能障碍，包括通透性增加、细胞增多和脑病。更全面地了解参与微生物穿越血脑屏障及相关屏障功能障碍的微生物-宿主相互作用，应有助于制定预防中枢神经系统感染的新策略。
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本文引用的文献
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Clin Infect Dis. 2008 Jun 1;46(11):1664-72. doi: 10.1086/587897.
2
Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005.2005年美国新出现的肺炎链球菌19A血清型的人群概况
J Infect Dis. 2008 Apr 1;197(7):1016-27. doi: 10.1086/528996.
3
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PLoS Pathog. 2007 Sep 7;3(9):1271-80. doi: 10.1371/journal.ppat.0030130.
4
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5
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J Lipid Res. 2007 Apr;48(4):782-93. doi: 10.1194/jlr.M600489-JLR200. Epub 2007 Jan 31.
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