Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, and Interuniversity Cardiology Institute Netherlands, Utrecht, the Netherlands.
Neth Heart J. 2007;15(9):318-22. doi: 10.1007/BF03086008.
At present, cardiac rhythm disorders such as sick sinus syndrome (SSS) or AV nodal block (AVB) are usually treated by electronic pacemakers. These devices have significant shortcomings, including lack of autonomic modulation, and the need for repetitive procedures for battery replacement or lead repositioning. Biological pacemakers as replacement or complement to electronic pacemakers have been the subject of increasing research interest. This research has resulted in many encouraging preclinical studies. Various approaches in the field of gene and cell therapy have been developed by different groups and this combined effort makes it increasingly realistic that this therapy will eventually find its way to clinical applicability. (Neth Heart J 2007;15:318-22.).
目前，心脏节律紊乱，如窦性心动过缓（SSS）或房室传导阻滞（AVB）通常采用电子起搏器进行治疗。这些设备存在显著缺陷，包括缺乏自主调节功能，需要重复进行电池更换或导线重新定位等程序。生物起搏器作为电子起搏器的替代品或补充物，已成为越来越多研究的课题。不同研究小组在基因和细胞治疗领域开展了各种方法的研究，这些共同的努力使得这种治疗方法最终实现临床应用的可能性越来越大。（Neth Heart J 2007;15:318-22.）
