Kanzaki Tatsuya, Horikawa Yoshiki, Makino Akira, Sugiyama Junji, Kimura Shunsaku
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Macromol Biosci. 2008 Nov 10;8(11):1026-33. doi: 10.1002/mabi.200800071.
Amphiphilic block polypeptides having a helical hydrophobic block with a uniform chain length and a hydrophilic nonionic block were newly synthesized and self-assembled into homogeneous nanotubes with ca. 60 nm diameter and ca. 200 nm length. The tubular assembly was shown to be elongated by heating over micrometer length without changing the diameter. Notably, a distinctive three-way nanotube was obtained just by mixing two kinds of amphiphilic polypeptides with the same helical hydrophobic block but different chain lengths of the hydrophilic block. The morphology of the molecular assemblies was shown to be tunable from a curved sheet-shaped assembly to a long or short nanotubular assembly and a three-way nanotubular assembly by suitable molecular design of the hydrophobic block, selection of the chain length of the hydrophilic block, mixing two-type block peptides, and processing such as heating.
新合成了具有链长均匀的螺旋疏水嵌段和亲水性非离子嵌段的两亲性嵌段多肽,它们自组装成直径约60 nm、长度约200 nm的均匀纳米管。通过加热,管状组装体可在不改变直径的情况下延长至微米长度。值得注意的是,仅通过混合两种具有相同螺旋疏水嵌段但亲水性嵌段链长不同的两亲性多肽,就能得到独特的三向纳米管。通过对疏水嵌段进行合适的分子设计、选择亲水性嵌段的链长、混合两种类型的嵌段肽以及加热等处理,分子组装体的形态可从弯曲的片状组装体调节为长或短的纳米管组装体以及三向纳米管组装体。